Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 11/20 | 0.49 |
| ▸ | PRKCA | P17252 | 3/20 | 0.46 |
| ▸ | CDK4 | P11802 | 4/20 | 0.40 |
| ▸ | CCND1 | P24385 | 4/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
| ▸ | PRKACB | P22694 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14440434 | 0.86 | TOP1 (0.44) | TOP1PRKCACDK4CCND1CCNE2 | |
| SCHEMBL14440332 | 0.84 | PRKCA (0.53) | TOP1PRKCACDK4CCND1CCNE2 | |
| SCHEMBL14440328 | 0.84 | PRKCA (0.53) | TOP1PRKCACDK4CCND1CCNE2 | |
| SCHEMBL8351770 | 0.83 | PRKCA (0.62) | PRKCACDK4CCND1CCNE2CCNE1 | |
| SCHEMBL14440433 | 0.80 | TOP1 (0.46) | TOP1PRKCACDK4CCND1CCNE2 | |
| SCHEMBL14440367 | 0.78 | TOP1 (0.49) | TOP1CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL14440365 | 0.75 | TOP1 (0.46) | TOP1CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL8354373 | 0.74 | PDGFRB (0.52) | TOP1CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL14440453 | 0.74 | PDGFRB (0.52) | TOP1CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL14440340 | 0.74 | MYLK (0.38) | TOP1CDK4CCND1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262215-B2 | N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors | NAD AG (DE) | 2007-08-28 | — | — | US | disclosed |
| US-7262215-B2 | N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors | NAD AG (DE) | 2007-08-28 | — | — | US | disclosed |