SCHEMBL144436

SCHEMBL144436

C=C1C[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]2(C)[C@@]1(O)C(C)=O

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.72
MEN1 O00255 3/20 0.72
KMT2A Q03164 3/20 0.72
TDP1 Q9NUW8 1/20 0.72
PGR P06401 3/20 0.70
AR P10275 3/20 0.70
CHRM1 P11229 2/20 0.70
SMN1; SMN2 Q16637 4/20 0.63
NR3C1 P04150 3/20 0.63
CYP2C9 P11712 2/20 0.63
HIF1A Q16665 2/20 0.63
NPSR1 Q6W5P4 2/20 0.63
CYP3A4 P08684 2/20 0.63
MAPK1 P28482 2/20 0.63
ABCB11 O95342 1/20 0.63
POLB P06746 1/20 0.63
CYP19A1 P11511 8/20 0.58
FNTA P49354 1/20 0.58
FNTB P49356 1/20 0.58
ADORA3 P0DMS8 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1650395 1.00 LMNA (0.72) LMNAMEN1KMT2ATDP1PGR
SCHEMBL10868391 1.00 LMNA (0.72) LMNAMEN1KMT2ATDP1PGR
Acetic Acid SCHEMBL4521 0.98 LMNA (0.70) LMNAMEN1KMT2ATDP1PGR
SCHEMBL8859777 0.92 LMNA (0.67) LMNAMEN1KMT2ATDP1PGR
Megestrol Acetate SCHEMBL5599601 0.90 AR (0.81) LMNAMEN1KMT2ATDP1PGR
SCHEMBL11513690 0.89 LMNA (0.58) LMNAMEN1KMT2ATDP1PGR
SCHEMBL11513687 0.89 LMNA (0.58) LMNAMEN1KMT2ATDP1PGR
SCHEMBL11512435 0.89 FNTA (0.73) LMNAMEN1KMT2ATDP1PGR
Melengestrol Acetate SCHEMBL10867312 0.84 LMNA (1.00) LMNAMEN1KMT2ATDP1PGR
Melengestrol Acetate SCHEMBL16389279 0.84 LMNA (1.00) LMNAMEN1KMT2ATDP1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2588 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240090533-A1 METHODS AND FORMULATIONS FOR REDUCING BOVINE EMISSIONS ELANCO US INC. 2024-03-21 US claimed
US-11864567-B2 Methods and formulations for reducing bovine emissions ELANCO US INC. (US) 2024-01-09 US claimed
EP-2116249-B2 Pharmaceutical compound containing gestagens and/or oestrogens and 5-methyl-(6S)-tetrahydrofolates BAYER IP GMBH (DE) 2023-04-05 EP claimed
EP-3441089-B1 TREATMENT METHODS USING ADENOVIRUS VASCULAR BIOGENICS LTD (IL) 2022-12-14 EP claimed
US-20220240545-A1 METHODS AND FORMULATIONS FOR REDUCING BOVINE EMISSIONS ELANCO US INC. 2022-08-04 US claimed
US-11344047-B2 Methods and formulations for reducing bovine emissions ELANCO US INC. (US) 2022-05-31 US claimed
CN-114365796-A Methods and formulations for reducing bovinae animal emissions 伊兰科美国公司 2022-04-19 CN claimed
US-20220073444-A1 Compounds, Compositions, and Methods for use in Treating Autophagy-Associated Disorders BIOPHAGY INC (US) 2022-03-10 US claimed
CN-108366583-B Methods and formulations for reducing bovinae animal emissions 伊兰科美国公司 2022-03-01 CN claimed
US-11208371-B2 Compounds, compositions, and methods for use in treating autophagy-associated disorders BIOPHAGY INC (US) 2021-12-28 US claimed
EP-0591432-A1 SOLUBILITY PARAMETER BASED DRUG DELIVERY SYSTEM AND METHOD FOR ALTERING DRUG SATURATION CONCENTRATION NOVEN PHARMACEUTICALS, INC. (US) 1994-04-13 EP claimed
EP-0573576-A1 COMPOSITIONS AND METHODS FOR TOPICAL ADMINISTRATION OF PHARMACEUTICALLY ACTIVE AGENTS. NOVEN PHARMA (US) 1993-12-15 EP claimed
US-5227167-A LONG-TERM DELIVERY DEVICE INCLUDING HYDROPHOBIC LOADING DOSE ALZA CORPORATION (US) 1993-07-13 US claimed
WO-1993000058-A1 SOLUBILITY PARAMETER BASED DRUG DELIVERY SYSTEM AND METHOD FOR ALTERING DRUG SATURATION CONCENTRATION NOVEN PHARMACEUTICALS, INC. (US) 1993-01-07 WO claimed
WO-1992015289-A1 COMPOSITIONS AND METHODS FOR TOPICAL ADMINISTRATION OF PHARMACEUTICALLY ACTIVE AGENTS NOVEN PHARMACEUTICALS, INC. (US) 1992-09-17 WO claimed
EP-0496520-A1 Novel bone acting agents MERCK & CO. INC. (US) 1992-07-29 EP claimed
US-4649042-A SUSTAINED RELEASE, DRUGS, GLYCOLIC ACID-LACTIC ACID COPOLYMER CORE, TUBES, ELASTICITY, SEALS ELI LILLY AND COMPANY (US) 1987-03-10 US claimed
US-4567001-A 16-Methylene-17α-hydroxy-progesterones THE UPJOHN COMPANY (US) 1986-01-28 US claimed
EP-0164241-A2 Improvements in or relating to a rumen delivery device ELI LILLY AND COMPANY (US) 1985-12-11 EP claimed
US-4346037-A Base catalyzed acylation with enol esters THE UPJOHN COMPANY (US) 1982-08-24 US claimed