Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.61 |
| ▸ | VCP | P55072 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1250 | 0.91 | NPC1 (0.71) | RAB9ANPC1MEN1KMT2APOLB | |
| SCHEMBL9261114 | 0.80 | MEN1 (0.57) | RAB9ANPC1MEN1KMT2APOLB | |
| SCHEMBL9263110 | 0.80 | NPC1 (0.70) | RAB9ANPC1MEN1KMT2APOLB | |
| SCHEMBL9260209 | 0.80 | NPC1 (0.57) | RAB9ANPC1MEN1KMT2APOLB | |
| SCHEMBL28302925 | 0.80 | MEN1 (0.66) | RAB9ANPC1MEN1KMT2APOLB | |
| SCHEMBL30056471 | 0.80 | RAB9A (0.61) | RAB9ANPC1MEN1KMT2APOLB | |
| SCHEMBL30056033 | 0.76 | RAB9A (0.89) | RAB9ANPC1MEN1KMT2APOLB | |
| SCHEMBL28301495 | 0.76 | RAB9A (1.00) | RAB9ANPC1MEN1KMT2APOLB | |
| SCHEMBL3599507 | 0.75 | GFER (0.60) | RAB9ANPC1MEN1KMT2APOLB | |
| SCHEMBL4104247 | 0.75 | MEN1 (0.58) | RAB9ANPC1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011032320-A1 | NOVEL ALKENE OXINDOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-24 | — | — | WO | disclosed |