Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 3/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3180067 | 0.82 | HSD17B10 (0.63) | GABRA5GABRB2HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL2895259 | 0.80 | GABRA5 (0.47) | GABRA5GABRB2HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL7795327 | 0.80 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9ATDP1LMNA | |
| SCHEMBL15709932 | 0.79 | ALDH1A1 (0.54) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL11926737 | 0.78 | HSD17B10 (0.70) | GABRA5GABRB2HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL1525238 | 0.77 | MEN1 (0.66) | SMN1; SMN2KMT2AMEN1LMNAPOLB | |
| SCHEMBL17115634 | 0.76 | ALDH1A1 (0.43) | GABRA5GABRB2HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL17115640 | 0.76 | KMT2A (0.65) | GABRA5GABRB2HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL17115621 | 0.73 | KMT2A (0.40) | GABRA5GABRB2HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL13936143 | 0.73 | TDP1 (0.38) | GABRA5GABRB2HSD17B10SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342779-A1 | INHIBITORS OF TRANSGLUTAMINASES | Zedira GmbH (DE) | 2018-07-04 | — | — | EP | disclosed |
| US-7247725-B2 | Gamma-aminoamide modulators of chemokine receptor activity | MERCK & CO., INC. (US) | 2007-07-24 | — | — | US | disclosed |