Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | VDR | P11473 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13721722 | 0.81 | TARBP2 (0.50) | GAAALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL1984902 | 0.77 | GAA (0.49) | GAAALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL12270194 | 0.77 | GAA (0.47) | GAAALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL2778196 | 0.74 | ALDH1A1 (0.74) | GAAALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL1981913 | 0.73 | GAA (0.49) | GAAALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL14504405 | 0.73 | KDM4E (0.63) | GAAALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL20646881 | 0.71 | GAA (0.64) | GAAALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL2789941 | 0.71 | GAA (0.73) | GAAALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL4425538 | 0.70 | PPARD (0.53) | GAAALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL6912084 | 0.70 | KDM4E (0.60) | KDM4EHPGDTARBP2LMNAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241780-B2 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method | BRISTOLS-MYERS SQUIBB COMPANY (US) | 2007-07-10 | — | — | US | disclosed |
| US-7241780-B2 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method | BRISTOLS-MYERS SQUIBB COMPANY (US) | 2007-07-10 | — | — | US | disclosed |