Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 7/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | VDR | P11473 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27505455 | 0.83 | VDR (0.41) | PPARDFFAR1VDRALDH1A1TSHR | |
| SCHEMBL4427114 | 0.80 | VDR (0.50) | PPARDFFAR1VDRTSHRGAA | |
| SCHEMBL3795755 | 0.79 | KDM4E (0.63) | PPARDFFAR1VDRALDH1A1GAA | |
| SCHEMBL820909 | 0.79 | SMN1; SMN2 (0.61) | PPARDFFAR1VDRALDH1A1TSHR | |
| SCHEMBL4426659 | 0.78 | PPARD (0.61) | PPARDFFAR1VDRALDH1A1PPARG | |
| SCHEMBL6377222 | 0.77 | KDM4E (0.51) | PPARDFFAR1VDRGAATARBP2 | |
| SCHEMBL4427371 | 0.76 | ALDH1A1 (0.38) | PPARDVDRALDH1A1TSHRKDM4E | |
| SCHEMBL14382241 | 0.75 | GAA (0.47) | PPARDFFAR1VDRALDH1A1TSHR | |
| SCHEMBL820892 | 0.74 | GAA (0.48) | PPARDFFAR1VDRALDH1A1GAA | |
| SCHEMBL2419932 | 0.73 | ALDH1A1 (0.47) | PPARDFFAR1VDRALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934311-B1 | NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES | BAYER HEALTHCARE AG (DE) | 2009-05-13 | — | — | EP | disclosed |
| EP-0934311-B1 | NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES | BAYER HEALTHCARE AG (DE) | 2009-05-13 | — | — | EP | disclosed |
| WO-2007065010-A2 | ANTI-ANGIOGENESIS COMPOUNDS | HIF BIO, INC. (US) | 2007-06-07 | — | — | WO | disclosed |
| EP-1686127-A1 | New heterocyclylmethyl-substituted pyrazole derivatives and their use for treating cardiovascular diseases | Bayer HealthCare AG (DE) | 2006-08-02 | — | — | EP | disclosed |
| US-6462068-B1 | CARDIOVASCULAR DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |
| US-6414009-B1 | CARDIOVASCULAR DISORDERS; ANTICOAGULANTS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-02 | — | — | US | disclosed |
| US-6410740-B1 | CYCLIZATION OF THE CORRESPONDING AMIDE | BAYER AKTIENGESELLSCHAFT (DE) | 2002-06-25 | — | — | US | disclosed |
| US-6387940-B1 | CARDIOVASCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-05-14 | — | — | US | disclosed |
| US-6166027-A | Heterocyclylmethyl-substituted pyrazole derivatives and their use for treating cardiovascular diseases | BAYER AKTIENGESELLSCHAFT (DE) | 2000-12-26 | — | — | US | disclosed |
| CN-1241188-A | Heterocyclylmethyl-substed pyrazol derivs. | BAYER AG (DE) | 2000-01-12 | — | — | CN | disclosed |
| EP-0934311-A2 | NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES | BAYER AG (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998016507-A2 | NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES AND THEIR USE FOR TREATING CARDIOVASCULAR DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-04-23 | — | — | WO | disclosed |