Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 12/20 | 0.46 |
| ▸ | TOP2B | Q02880 | 12/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL143295 | 0.73 | TOP2A (0.60) | TOP2ATOP2BLMNAPOLBPIK3CD | |
| Bicarbonate SCHEMBL9047917 | 0.72 | TOP2A (0.58) | TOP2ATOP2B | |
| SCHEMBL10808897 | 0.71 | TOP2A (0.62) | TOP2ATOP2B | |
| SCHEMBL8452757 | 0.71 | TOP2A (0.53) | TOP2ATOP2B | |
| SCHEMBL30906940 | 0.70 | MAT2A (0.45) | TOP2ATOP2BAOC3 | |
| SCHEMBL29742967 | 0.70 | TOP2A (0.49) | TOP2ATOP2BLMNAPIK3CDPIK3R1 | |
| SCHEMBL10475103 | 0.70 | TOP2A (0.49) | TOP2ATOP2BLMNAPIK3CDPIK3R1 | |
| Bicarbonate SCHEMBL11112814 | 0.70 | TOP2A (0.58) | TOP2ATOP2B | |
| Hydrochloric Acid SCHEMBL29744471 | 0.69 | TOP2A (0.48) | TOP2ATOP2BLMNAPIK3CDPIK3R1 | |
| SCHEMBL10510897 | 0.69 | TOP2A (0.54) | TOP2ATOP2BJAK2JAK1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058989-A1 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058989-A1 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | RECQL, BLVRB, NQO2 | TOP2A 125/4885TOP2B 31/4885LMNA 2216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.