Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 11/20 | 0.67 |
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14453586 | 0.83 | GAA (0.50) | GAAMAPTPOLBL3MBTL1 | |
| SCHEMBL14453680 | 0.80 | GAA (0.47) | GAAMAPTPOLBKMT2AMEN1 | |
| SCHEMBL14453682 | 0.79 | THRB (0.50) | GAAMAPTPOLBLMNAKMT2A | |
| SCHEMBL13678600 | 0.78 | MAPK1 (0.53) | GAAMAPTPOLBLMNAKMT2A | |
| SCHEMBL28876849 | 0.77 | ALDH1A1 (0.50) | GAAMAPTPOLBLMNAKMT2A | |
| SCHEMBL27534191 | 0.76 | MAPK1 (0.53) | GAAMAPTPOLBLMNAKMT2A | |
| SCHEMBL27801673 | 0.76 | ALDH1A1 (0.49) | GAAMAPTPOLBLMNAKMT2A | |
| SCHEMBL14453679 | 0.76 | ALDH1A1 (0.49) | GAAMAPTLMNAKMT2ASMN1; SMN2 | |
| SCHEMBL6478819 | 0.76 | ALDH1A1 (0.49) | GAAMAPTPOLBLMNAKMT2A | |
| SCHEMBL8003279 | 0.76 | ALDH1A1 (0.49) | GAAMAPTPOLBLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161677-A1 | Bisarylurea derivatives | MERCK PATENT GMBH (DE) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161677-A1 | Bisarylurea derivatives | BRAF, RAF1, NRAS | GAA 1401/4885MAPT 2288/4885POLB 919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.