Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.35 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.35 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25443839 | 0.92 | HRH3 (0.48) | HRH3KCNH2CYP2D6NAMPTALDH1A1 | |
| SCHEMBL18390493 | 0.86 | NAMPT (0.51) | HRH3KCNH2CYP2D6NAMPTALDH1A1 | |
| SCHEMBL12026454 | 0.84 | NAMPT (0.43) | HRH3KCNH2CYP2D6NAMPTTPSAB1 | |
| SCHEMBL24671513 | 0.84 | ALDH1A1 (0.50) | HRH3KCNH2CYP2D6NAMPTALDH1A1 | |
| SCHEMBL10232843 | 0.80 | HRH3 (0.39) | HRH3KCNH2ALDH1A1 | |
| SCHEMBL17190311 | 0.80 | HRH3 (0.36) | HRH3KCNH2CYP2D6ALDH1A1 | |
| SCHEMBL18704939 | 0.79 | HRH3 (0.47) | HRH3KCNH2CYP2D6NAMPT | |
| SCHEMBL25443838 | 0.79 | NAMPT (0.42) | HRH3KCNH2CYP2D6NAMPTALDH1A1 | |
| SCHEMBL1913158 | 0.79 | L3MBTL1 (0.42) | HRH3NAMPTKDM4EL3MBTL1 | |
| SCHEMBL20088227 | 0.78 | HRH3 (0.36) | HRH3KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7247634-B2 | Rifamycin derivatives effective against drug-resistant microbes | CUMBRE PHARMACEUTICALS INC. (US) | 2007-07-24 | — | — | US | disclosed |
| US-7238694-B2 | Rifamycin imino derivatives effective against drug-resistant microbes | CUMBRE PHARMACEUTICALS, INC. (US) | 2007-07-03 | — | — | US | disclosed |