Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1445828 | 0.84 | CYP2A6 (0.43) | SMN1; SMN2PDE3ACYP3A4MAPK1LMNA | |
| SCHEMBL1445846 | 0.81 | CYP2A6 (0.43) | SMN1; SMN2PDE3ACYP3A4MAPK1LMNA | |
| SCHEMBL1445844 | 0.81 | CYP2A6 (0.46) | SMN1; SMN2PDE3ACYP3A4MAPK1LMNA | |
| SCHEMBL1445678 | 0.80 | HPGD (0.50) | SMN1; SMN2MEN1KMT2AALDH1A1GAA | |
| SCHEMBL1445805 | 0.79 | HPGD (0.55) | SMN1; SMN2LMNACYP2A6ALDH1A1KDM4E | |
| SCHEMBL1445433 | 0.79 | ACHE (0.41) | SMN1; SMN2PDE3ACYP3A4MAPK1LMNA | |
| SCHEMBL1445687 | 0.78 | CYP2A6 (0.50) | SMN1; SMN2PDE3ACYP3A4MAPK1LMNA | |
| SCHEMBL1446097 | 0.78 | PARP1 (0.46) | SMN1; SMN2PDE3ACYP3A4MAPK1LMNA | |
| SCHEMBL1446546 | 0.78 | MEN1 (0.54) | SMN1; SMN2CYP3A4MAPK1LMNACYP1A2 | |
| SCHEMBL1445608 | 0.78 | TLR8 (0.41) | SMN1; SMN2PDE3ACYP3A4MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101285061-A | Fungal cell wall synthetic genes | EISAI R&D MAN CO LTD (JP) | 2008-10-15 | — | — | CN | claimed |
| CN-1249227-C | Fungal cell wall synthetic genes | EISAI CO LTD (JP) | 2006-04-05 | — | — | CN | claimed |
| US-20040038239-A1 | Fungal cell wall synthesis gene | EISAI CO., LTD. (JP) | 2004-02-26 | — | — | US | claimed |
| CN-1449443-A | Fungal cell wall synthetic genes | EISAI CO LTD (JP) | 2003-10-15 | — | — | CN | claimed |
| EP-1300464-A1 | FUNGAL CELL WALL SYNTHESIS GENE | Eisai Co., Ltd. (JP) | 2003-04-09 | — | — | EP | claimed |
| US-7999090-B2 | reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered; antifungal agents; inhibiting expression of cell wall glycoproteins and preventing pathogens from showing pathogenicity; DNA | EISAI CO., LTD (JP) | 2011-08-16 | — | — | US | disclosed |
| US-7928209-B2 | reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered; antifungal agents; inhibiting expression of cell wall glycoproteins and preventing pathogens from showing pathogenicity; DNA | EISAI R & D MANAGEMENT CO. LTD. (JP) | 2011-04-19 | — | — | US | disclosed |
| US-7910712-B2 | Fungal cell wall synthesis gene | EISAI R&D MANAGEMENT CO., LTD (JP) | 2011-03-22 | — | — | US | disclosed |
| US-7897387-B2 | Fungal cell wall synthesis gene | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-03-01 | — | — | US | disclosed |
| US-20090325228-A1 | FUNGAL CELL WALL SYNTHESIS GENE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-12-31 | — | — | US | disclosed |
| US-7541332-B2 | Fungal cell wall synthesis gene | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-02 | — | — | US | disclosed |
| US-20090117586-A1 | FUNGAL CELL WALL SYNTHESIS GENE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-05-07 | — | — | US | disclosed |
| CN-1873002-A | Fungal cell wall synthesis gene | EISAI CO LTD (JP) | 2006-12-06 | — | — | CN | disclosed |
| CN-1873003-A | Fungal cell wall synthesis gene | EISAI CO LTD (JP) | 2006-12-06 | — | — | CN | disclosed |
| US-20060234283-A1 | Fungal cell wall synthesis gene | EISAI CO., LTD. (JP) | 2006-10-19 | — | — | US | disclosed |
| US-20060234349-A1 | Fungal cell wall synthesis gene | EISAI CO., LTD. (JP) | 2006-10-19 | — | — | US | disclosed |
| CN-1249227-C | Fungal cell wall synthetic genes | EISAI CO LTD (JP) | 2006-04-05 | — | — | CN | disclosed |
| US-20040038239-A1 | Fungal cell wall synthesis gene | EISAI CO., LTD. (JP) | 2004-02-26 | — | — | US | disclosed |
| CN-1449443-A | Fungal cell wall synthetic genes | EISAI CO LTD (JP) | 2003-10-15 | — | — | CN | disclosed |
| EP-1300464-A1 | FUNGAL CELL WALL SYNTHESIS GENE | Eisai Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325228-A1 | FUNGAL CELL WALL SYNTHESIS GENE | ERG28, GPI, DPM1 | SMN1; SMN2 4885/4885PDE3A 2126/4885CYP3A4 2196/4885 |
| US-20040038239-A1 | Fungal cell wall synthesis gene | ERG28, GPI, DPM1 | SMN1; SMN2 4885/4885PDE3A 2126/4885CYP3A4 2196/4885 |
| US-20060234349-A1 | Fungal cell wall synthesis gene | ERG28, GPI, DPM1 | SMN1; SMN2 4885/4885PDE3A 2126/4885CYP3A4 2196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.