Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 7/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5271241 | 0.83 | HSP90AA1 (0.49) | MAPTMEN1KMT2AALDH1A1ALOX15 | |
| SCHEMBL5270664 | 0.73 | MAPT (0.47) | MAPTMEN1KMT2AALDH1A1ALOX15 | |
| SCHEMBL14396298 | 0.73 | MAPT (0.49) | MAPTMEN1KMT2AALDH1A1ALOX15 | |
| SCHEMBL14396113 | 0.72 | MEN1 (0.61) | MAPTMEN1KMT2AALDH1A1ALOX12 | |
| SCHEMBL717437 | 0.72 | ALOX12 (0.61) | MAPTMEN1KMT2AALDH1A1ALOX15 | |
| SCHEMBL14396294 | 0.71 | MEN1 (0.54) | MAPTMEN1KMT2AALOX15MAPK1 | |
| SCHEMBL4882770 | 0.71 | ALOX12 (0.54) | MAPTMEN1KMT2AALDH1A1ALOX15 | |
| SCHEMBL5272655 | 0.71 | MEN1 (0.45) | MAPTMEN1KMT2AALDH1A1ALOX15 | |
| SCHEMBL14396291 | 0.69 | HSP90AA1 (0.62) | MAPTMEN1KMT2AALDH1A1ALOX15 | |
| SCHEMBL5333040 | 0.69 | GAA (0.69) | MAPTMEN1KMT2AALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7247734-B2 | 3,4-diarylpyrazoles and their use in the therapy of cancer | VERNALIS (CAMBRIDGE) LIMITED (GB) | 2007-07-24 | — | — | US | disclosed |