Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27364335 | 0.83 | MLYCD (0.32) | MEN1KMT2ATDP1PKMRAB9A | |
| SCHEMBL20640958 | 0.81 | MLYCD (0.34) | MEN1KMT2ATDP1PKMRAB9A | |
| SCHEMBL23989852 | 0.80 | MLYCD (0.35) | PKMRAB9A | |
| SCHEMBL12388915 | 0.79 | SMN1; SMN2 (0.36) | MEN1KMT2A | |
| SCHEMBL1558801 | 0.77 | — | — | |
| SCHEMBL25255150 | 0.77 | MEN1 (0.34) | MEN1KMT2ATDP1PKMRAB9A | |
| SCHEMBL13849316 | 0.76 | MAPK1 (0.30) | — | |
| SCHEMBL28976591 | 0.75 | — | — | |
| SCHEMBL5043804 | 0.74 | ALDH1A1 (0.42) | MEN1KMT2ARAB9A | |
| SCHEMBL13136901 | 0.73 | MEN1 (0.32) | MEN1KMT2ATDP1PKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4630405-A1 | PROCESS FOR THE SYNTHESIS OF SUBSTITUTED TETRAHYDROFURAN MODULATORS OF SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024123815-A1 | PROCESS FOR THE SYNTHESIS OF SUBSTITUTED TETRAHYDROFURAN MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2024-06-13 | — | — | WO | disclosed |
| EP-4347032-A1 | SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2024-04-10 | — | — | EP | disclosed |
| CN-117813302-A | Substituted tetrahydrofuran-2-carboxamides as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2024-04-02 | — | — | CN | disclosed |
| WO-2022256702-A1 | SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-12-08 | — | — | WO | disclosed |
| WO-2011023706-A1 | PROCESS FOR THE PREPARATION OF A GLUCOKINASE ACTIVATOR COMPOUND | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-03 | — | — | WO | disclosed |
| US-20110054174-A1 | PROCESS FOR THE PREPARATION OF A GLUCOKINASE ACTIVATOR COMPOUND | HOFFMANN-LA ROCHE, INC. | 2011-03-03 | — | — | US | disclosed |
| US-20110054174-A1 | PROCESS FOR THE PREPARATION OF A GLUCOKINASE ACTIVATOR COMPOUND | HOFFMANN-LA ROCHE, INC. | 2011-03-03 | — | — | US | disclosed |
| US-20110054174-A1 | PROCESS FOR THE PREPARATION OF A GLUCOKINASE ACTIVATOR COMPOUND | HOFFMANN-LA ROCHE, INC. | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110054174-A1 | PROCESS FOR THE PREPARATION OF A GLUCOKINASE ACTIVATOR COMPOUND | GCKR, GCK, HK1 | MEN1 2762/4885KMT2A 2741/4885TDP1 3558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.