Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14456910 | 0.89 | CYP3A4 (0.54) | CYP3A4MEN1KMT2AALOX15TSHR | |
| SCHEMBL14456681 | 0.88 | KMT2A (0.52) | MEN1KMT2ATBK1ALOX15TSHR | |
| SCHEMBL14456919 | 0.88 | CYP3A4 (0.61) | CYP3A4 | |
| SCHEMBL8223229 | 0.86 | TBK1 (0.51) | MEN1KMT2ATBK1ALOX15TSHR | |
| SCHEMBL14456744 | 0.86 | KMT2A (0.56) | CYP3A4MEN1KMT2AALOX15TSHR | |
| SCHEMBL18985960 | 0.85 | TBK1 (0.60) | CYP3A4TBK1 | |
| SCHEMBL14456951 | 0.84 | L3MBTL1 (0.56) | CYP3A4TBK1 | |
| SCHEMBL14456927 | 0.84 | CYP3A4 (0.54) | CYP3A4 | |
| SCHEMBL14456906 | 0.83 | EPHX2 (0.52) | CYP3A4 | |
| SCHEMBL14456913 | 0.83 | CYP3A4 (0.52) | CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| US-7238688-B2 | Piperidine compounds | SCHERING CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |
| US-7238688-B2 | Piperidine compounds | SCHERING CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |