Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | LSS | P48449 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14456986 | 0.92 | POLB (0.55) | CYP3A4POLBLMNAALDH1A1TSHR | |
| SCHEMBL14456987 | 0.90 | CYP3A4 (0.61) | CYP3A4POLBCYP2C19LMNA | |
| SCHEMBL14456977 | 0.89 | POLB (0.56) | CYP3A4POLBHTTLMNAALDH1A1 | |
| SCHEMBL14456996 | 0.88 | POLB (0.51) | CYP3A4POLBLMNAALDH1A1TSHR | |
| SCHEMBL14456903 | 0.86 | CYP3A4 (0.53) | CYP3A4POLBCYP2C19LMNA | |
| SCHEMBL14456976 | 0.85 | POLB (0.52) | CYP3A4POLBLMNAALDH1A1TSHR | |
| SCHEMBL14457004 | 0.84 | ALDH1A1 (0.54) | CYP3A4POLBLMNAALDH1A1TSHR | |
| SCHEMBL14456975 | 0.84 | CNR1 (0.60) | CYP3A4POLBLMNAALDH1A1TSHR | |
| SCHEMBL14456964 | 0.84 | CNR1 (0.60) | CYP3A4POLBLMNAALDH1A1TSHR | |
| SCHEMBL14456974 | 0.82 | CYP3A4 (0.53) | CYP3A4POLBLMNAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| US-7238688-B2 | Piperidine compounds | SCHERING CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |
| US-7238688-B2 | Piperidine compounds | SCHERING CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |