Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.43 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 3/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5621353 | 1.00 | DRD2 (0.43) | DRD2DRD3KCNH2MBTD1L3MBTL3 | |
| SCHEMBL5621365 | 0.88 | MBTD1 (0.39) | DRD2DRD3KCNH2MBTD1L3MBTL3 | |
| SCHEMBL5764603 | 0.88 | DRD2 (0.47) | DRD2DRD3KCNH2MBTD1L3MBTL3 | |
| SCHEMBL5107142 | 0.86 | SMN1; SMN2 (0.46) | MBTD1L3MBTL3SMN1; SMN2TDP1RORC | |
| SCHEMBL5622421 | 0.86 | MBTD1 (0.39) | DRD2DRD3KCNH2MBTD1L3MBTL3 | |
| SCHEMBL5622388 | 0.86 | MBTD1 (0.39) | DRD2DRD3KCNH2MBTD1L3MBTL3 | |
| SCHEMBL5621061 | 0.86 | MBTD1 (0.39) | DRD2DRD3KCNH2MBTD1L3MBTL3 | |
| Hydrochloric Acid SCHEMBL5107646 | 0.85 | SMN1; SMN2 (0.45) | MBTD1L3MBTL3SMN1; SMN2TDP1RORC | |
| SCHEMBL5620557 | 0.85 | DRD2 (0.46) | DRD2DRD3KCNH2SIGMAR1GRIN2B | |
| SCHEMBL5622611 | 0.85 | DRD2 (0.46) | DRD2DRD3KCNH2SIGMAR1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070173525-A1 | Tyrosine kinase inhibitors | MERCK SHARP & DOHME CORP. | 2007-07-26 | — | — | US | disclosed |
| US-20070173525-A1 | Tyrosine kinase inhibitors | MERCK SHARP & DOHME CORP. | 2007-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173525-A1 | Tyrosine kinase inhibitors | ABL1, JAK2, ERBB2 | DRD2 1517/4885DRD3 1813/4885KCNH2 1155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.