Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24786715 | 0.89 | BRD4 (0.36) | BRD4BRD2PIK3CDLMNACA12 | |
| SCHEMBL7620731 | 0.89 | BRD4 (0.36) | BRD4BRD2PIK3CDLMNACA12 | |
| SCHEMBL25662213 | 0.86 | PIK3CD (0.43) | BRD4BRD2PIK3CDLMNACA12 | |
| SCHEMBL24787679 | 0.86 | BRD4 (0.34) | BRD4BRD2PIK3CDLMNACA12 | |
| SCHEMBL21117768 | 0.84 | BRD4 (0.39) | BRD4BRD2PIK3CDLMNACA12 | |
| SCHEMBL3656227 | 0.83 | BRD4 (0.41) | BRD4BRD2PIK3CDLMNACA12 | |
| SCHEMBL10093754 | 0.83 | BRD4 (0.41) | BRD4BRD2PIK3CDLMNACA12 | |
| SCHEMBL19918750 | 0.82 | MITF (0.33) | BRD4BRD2ALDH1A1PER2 | |
| SCHEMBL21922559 | 0.78 | ALOX5 (0.41) | BRD4BRD2PIK3CDLMNACA12 | |
| SCHEMBL18799294 | 0.78 | ALOX5 (0.41) | BRD4BRD2PIK3CDLMNACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7244738-B2 | Arylamine-substituted quinazolinone compounds useful as alpha 1A/B adrenergic receptor antagonists | ROCHE PALO ALTO LLC (US) | 2007-07-17 | — | — | US | disclosed |
| US-7244738-B2 | Arylamine-substituted quinazolinone compounds useful as alpha 1A/B adrenergic receptor antagonists | ROCHE PALO ALTO LLC (US) | 2007-07-17 | — | — | US | disclosed |