Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15112114 | 0.92 | PTGS2 (0.48) | LIMK1MAPTPTGS2TP53KDM4E | |
| SCHEMBL5630969 | 0.85 | CSNK2A2 (0.51) | LIMK1MAPTTP53KDM4ETSHR | |
| SCHEMBL16751134 | 0.83 | LIMK1 (0.77) | LIMK1MAPTPTGS2TP53KDM4E | |
| SCHEMBL15933742 | 0.83 | LIMK1 (0.77) | LIMK1MAPTPTGS2TP53KDM4E | |
| SCHEMBL5629554 | 0.83 | LIMK1 (0.77) | LIMK1MAPTPTGS2TP53KDM4E | |
| SCHEMBL16384793 | 0.83 | LIMK1 (0.77) | LIMK1MAPTPTGS2TP53KDM4E | |
| SCHEMBL10343608 | 0.82 | HTT (0.63) | LIMK1MAPTTP53KDM4ETSHR | |
| SCHEMBL19523758 | 0.82 | HTT (0.63) | LIMK1MAPTTP53KDM4ETSHR | |
| SCHEMBL12429192 | 0.80 | KDM4E (0.58) | LIMK1MAPTPTGS2TP53KDM4E | |
| SCHEMBL15112168 | 0.80 | PTGS2 (0.48) | LIMK1MAPTPTGS2TP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7238701-B2 | Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders | BAYER PHARMACEUTICALS CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |
| US-7238701-B2 | Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders | BAYER PHARMACEUTICALS CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |