Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26964 | 0.85 | NR3C1 (0.55) | POLBNR3C1DRD2DRD4DRD3 | |
| SCHEMBL14585018 | 0.83 | AR (0.54) | POLBSMN1; SMN2HPGDARALDH1A1 | |
| SCHEMBL13542850 | 0.81 | TOP2A (0.57) | POLBNR3C1DRD2DRD4DRD3 | |
| SCHEMBL5262193 | 0.81 | NR3C1 (0.56) | POLBNR3C1DRD2DRD4DRD3 | |
| SCHEMBL7902370 | 0.81 | PTGS1 (0.59) | POLBNR3C1DRD2DRD4DRD3 | |
| SCHEMBL2767849 | 0.80 | POLB (0.57) | POLBNR3C1DRD2DRD4DRD3 | |
| SCHEMBL2284909 | 0.79 | HTR6 (0.64) | POLBNR3C1DRD2DRD4DRD3 | |
| SCHEMBL14345545 | 0.79 | NR3C1 (0.55) | POLBNR3C1DRD2DRD4DRD3 | |
| SCHEMBL30240812 | 0.79 | NR3C1 (0.59) | POLBNR3C1DRD2DRD4DRD3 | |
| SCHEMBL3560306 | 0.79 | IKBKB (0.58) | POLBNR3C1DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644343-B1 | 5-SUBSTITUTED QUINAZOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2007-07-04 | — | — | EP | disclosed |