SCHEMBL1446485

SCHEMBL1446485

COc1cc(Cl)c(C(=O)Nc2nc(C(=O)NCCN(C(C)C)C(C)C)cs2)cc1OC

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.81
LMNA P02545 2/20 0.42
NPSR1 Q6W5P4 1/20 0.42
HSD17B10 Q99714 1/20 0.42
HPGD P15428 1/20 0.41
TSHR P16473 1/20 0.41
PANK3 Q9H999 1/20 0.41
MME P08473 1/20 0.40
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
POLB P06746 1/20 0.38
CPT1A P50416 2/20 0.38
CPT1B Q92523 2/20 0.38
RAB9A P51151 2/20 0.37
KDM4E B2RXH2 1/20 0.37
NPC1 O15118 1/20 0.37
MITF O75030 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
PDE5A O76074 1/20 0.36
HTR3E A5X5Y0 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6975610 0.99 ACHE (0.81) ACHELMNANPSR1HSD17B10HPGD
Hydrochloric Acid SCHEMBL6975822 0.92 ACHE (0.75) ACHELMNANPSR1HSD17B10HPGD
SCHEMBL28440118 0.91 ACHE (0.85) ACHELMNANPSR1HSD17B10HPGD
Acotiamide SCHEMBL28293346 0.90 ACHE (1.00) ACHELMNANPSR1HSD17B10HPGD
Acotiamide SCHEMBL1043131 0.90 ACHE (1.00) ACHELMNANPSR1HSD17B10HPGD
Acotiamide SCHEMBL30872102 0.90 ACHE (1.00) ACHELMNANPSR1HSD17B10HPGD
Acotiamide SCHEMBL6968566 0.89 ACHE (1.00) ACHELMNANPSR1HSD17B10HPGD
Hydrochloric Acid SCHEMBL6976088 0.89 ACHE (0.65) ACHELMNANPSR1HSD17B10HPGD
Hydrochloric Acid SCHEMBL6973844 0.88 ACHE (0.81) ACHELMNANPSR1HSD17B10HPGD
SCHEMBL28021509 0.88 ACHE (0.63) ACHELMNANPSR1HSD17B10HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200375954-A1 THERAPEUTIC AGENT FOR FOOD COMPETENCE DISORDER IN STOMACH ZERIA PHARMACEUTICAL CO., LTD. (JP) 2020-12-03 US disclosed
US-20150141475-A1 THERAPEUTIC AGENT FOR FOOD COMPETENCE DISORDER IN STOMACH ZERIA PHARMACEUTICAL CO., LTD. (JP) 2015-05-21 US disclosed
EP-1493441-B1 THERAPEUTIC AGENT FOR FOOD COMPETENCE DISORDER IN STOMACH ZERIA PHARM CO LTD (JP) 2011-08-31 EP disclosed
EP-2301540-A1 A therapeutic agent for impaired gastric accomodation Zeria Pharmaceutical Co., Ltd. (JP) 2011-03-30 EP disclosed
US-20090156652-A1 THERAPEUTIC AGENT FOR FOOD COMPETENCE DISORDER IN STOMACH ZERIA PHARMACEUTICAL CO., LTD. (JP) 2009-06-18 US disclosed
US-20050176788-A1 Therapeutic agent for food competence disorder in stomach ZERIA PHARMACEUTICAL CO., LTD. 2005-08-11 US disclosed
EP-1493441-A1 THERAPEUTIC AGENT FOR FOOD COMPETENCE DISORDER IN STOMACH Zeria Pharmaceutical Co., Ltd. (JP) 2005-01-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200375954-A1 THERAPEUTIC AGENT FOR FOOD COMPETENCE DISORDER IN STOMACH GIPR, GRPR, HRH2 ACHE 952/4885LMNA 4290/4885NPSR1 223/4885
US-20090156652-A1 THERAPEUTIC AGENT FOR FOOD COMPETENCE DISORDER IN STOMACH GIPR, GRPR, HRH2 ACHE 952/4885LMNA 4290/4885NPSR1 223/4885
US-20050176788-A1 Therapeutic agent for food competence disorder in stomach GIPR, GRPR, HRH2 ACHE 952/4885LMNA 4290/4885NPSR1 223/4885
US-20150141475-A1 THERAPEUTIC AGENT FOR FOOD COMPETENCE DISORDER IN STOMACH GIPR, GRPR, HRH2 ACHE 952/4885LMNA 4290/4885NPSR1 223/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.