Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acotiamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 3/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acotiamide SCHEMBL1043131 | 1.00 | ACHE (1.00) | ACHELMNANPSR1HSD17B10TSHR | |
| Acotiamide SCHEMBL30872102 | 1.00 | ACHE (1.00) | ACHELMNANPSR1HSD17B10TSHR | |
| Acotiamide SCHEMBL6968566 | 0.99 | ACHE (1.00) | ACHELMNANPSR1HSD17B10TSHR | |
| Acotiamide SCHEMBL29362154 | 0.98 | ACHE (0.98) | ACHELMNANPSR1HSD17B10TSHR | |
| Acotiamide SCHEMBL27938245 | 0.98 | ACHE (0.98) | ACHELMNANPSR1HSD17B10TSHR | |
| Hydrochloric Acid SCHEMBL6975742 | 0.94 | ACHE (0.91) | ACHELMNANPSR1HSD17B10TSHR | |
| Hydrochloric Acid SCHEMBL6973893 | 0.94 | ACHE (0.91) | ACHELMNANPSR1HSD17B10TSHR | |
| SCHEMBL27703668 | 0.94 | ACHE (0.88) | ACHELMNANPSR1HSD17B10TSHR | |
| Hydrochloric Acid SCHEMBL27944898 | 0.93 | ACHE (0.88) | ACHELMNANPSR1HSD17B10TSHR | |
| SCHEMBL6972097 | 0.93 | ACHE (0.86) | ACHELMNANPSR1HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109608412-A | A kind of improved acotiamide hydrochloride hydrate synthetic method | 开封制药(集团)有限公司 | 2019-04-12 | — | — | CN | claimed |