Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2630097 | 0.80 | — | — | |
| SCHEMBL2633718 | 0.79 | JAK2 (0.44) | — | |
| SCHEMBL2630379 | 0.79 | — | — | |
| SCHEMBL12929629 | 0.77 | ALDH1A1 (0.58) | MEN1KMT2AL3MBTL1LMNATP53 | |
| SCHEMBL12929363 | 0.76 | MEN1 (0.60) | MEN1KMT2AL3MBTL1LMNATP53 | |
| SCHEMBL12929527 | 0.76 | ALDH1A1 (0.57) | MEN1KMT2AL3MBTL1LMNATP53 | |
| SCHEMBL12929476 | 0.76 | MEN1 (0.59) | MEN1KMT2AL3MBTL1LMNATP53 | |
| SCHEMBL12929466 | 0.74 | MEN1 (0.60) | MEN1KMT2AL3MBTL1LMNATP53 | |
| SCHEMBL21902520 | 0.74 | JAK2 (0.35) | ALDH1A1KDM4E | |
| SCHEMBL12929414 | 0.74 | MEN1 (0.59) | MEN1KMT2AL3MBTL1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007084557-A2 | AZAINDOLES USEFUL AS INHIBITORS OF JANUS KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-07-26 | — | — | WO | disclosed |