Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9690927 | 1.00 | TDP1 (0.67) | TDP1ALDH1A1MAPTLMNAGAA | |
| SCHEMBL13527924 | 0.89 | TDP1 (0.80) | TDP1ALDH1A1MAPTLMNAGAA | |
| SCHEMBL10537902 | 0.83 | MAPT (0.45) | TDP1ALDH1A1MAPTLMNAGAA | |
| SCHEMBL7167731 | 0.82 | TDP1 (0.69) | TDP1ALDH1A1MAPTLMNAGAA | |
| SCHEMBL9000125 | 0.80 | TDP1 (0.67) | TDP1ALDH1A1MAPTLMNAGAA | |
| SCHEMBL1014744 | 0.80 | TDP1 (0.67) | TDP1ALDH1A1MAPTLMNAGAA | |
| SCHEMBL28470699 | 0.80 | TDP1 (0.67) | TDP1ALDH1A1MAPTLMNAGAA | |
| SCHEMBL14466269 | 0.80 | TDP1 (0.67) | TDP1ALDH1A1MAPTLMNAGAA | |
| SCHEMBL1421341 | 0.80 | TDP1 (1.00) | TDP1ALDH1A1MAPTLMNAGAA | |
| SCHEMBL8252775 | 0.80 | TDP1 (0.67) | TDP1ALDH1A1MAPTLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007084415-A2 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2007-07-26 | — | — | WO | disclosed |