Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14425984 | 0.82 | NOTUM (0.57) | NOTUMAKT1SLC18A3SIGMAR1HDAC1 | |
| SCHEMBL1713442 | 0.82 | AXL (0.46) | POLBAKT1 | |
| SCHEMBL13001191 | 0.81 | AKT1 (0.43) | NOTUMPOLBAKT1SIGMAR1 | |
| SCHEMBL12999388 | 0.81 | AXL (0.37) | NOTUMPOLBAKT1 | |
| SCHEMBL12084772 | 0.80 | AXL (0.36) | NOTUMPOLB | |
| SCHEMBL13000644 | 0.79 | MEN1 (0.41) | POLBAKT1SIGMAR1 | |
| SCHEMBL13000501 | 0.79 | CTSS (0.39) | POLB | |
| SCHEMBL14580805 | 0.79 | OPRM1 (0.44) | — | |
| SCHEMBL5578657 | 0.79 | HTT (0.40) | NOTUMMAPK1 | |
| SCHEMBL12999808 | 0.79 | EPHX2 (0.37) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076070-A2 | MODULATORS OF MUSCARINIC RECEPTORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-07-05 | — | — | WO | disclosed |