Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 19/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5411319 | 0.82 | ADORA2A (0.81) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL14468280 | 0.82 | ADORA2A (0.51) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL26756885 | 0.80 | ADORA3 (0.51) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL5764372 | 0.79 | ADORA2A (0.62) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL5405484 | 0.77 | NPC1 (0.53) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL4372964 | 0.77 | ADORA2A (0.78) | ADORA2A | |
| SCHEMBL1837333 | 0.77 | ADORA2A (0.55) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL5416149 | 0.74 | ADORA2A (0.80) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL4369992 | 0.73 | ADORA2A (0.67) | ADORA2A | |
| SCHEMBL5414368 | 0.73 | ADORA2A (0.72) | ADORA2AADORA3ADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7238676-B2 | Purine derivatives | PFIZER INC. (US) | 2007-07-03 | — | — | US | disclosed |