Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 12/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14468874 | 0.95 | F2R (0.81) | F2RALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12167175 | 0.95 | F2R (0.81) | F2RALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14469006 | 0.93 | F2R (0.71) | F2RSMN1; SMN2MAPTL3MBTL1GAA | |
| SCHEMBL15501075 | 0.92 | F2R (0.70) | F2RALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14469086 | 0.92 | F2R (0.69) | F2RALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14468966 | 0.91 | F2R (0.69) | F2RKDM4EMAPTLMNA | |
| SCHEMBL12167167 | 0.91 | F2R (0.82) | F2R | |
| SCHEMBL14468937 | 0.91 | F2R (0.68) | F2RALDH1A1KMT2ASMN1; SMN2KDM4E | |
| Atopaxar SCHEMBL30175034 | 0.90 | F2R (1.00) | F2RALDH1A1MEN1KMT2ASMN1; SMN2 | |
| Atopaxar SCHEMBL1730339 | 0.90 | F2R (1.00) | F2RALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8658620-B2 | Pharmaceutical composition, use of 2-iminopyrrolidine derivative for production of pharmaceutical composition, and kit for treatment or amelioration of heart diseases | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-02-25 | — | — | US | disclosed |
| US-7244730-B2 | 2-iminopyrrolidine derivatives | EISAI CO., LTD (JP) | 2007-07-17 | — | — | US | disclosed |