Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14469188 | 0.85 | ALDH1A1 (0.46) | POLBALDH1A1SMN1; SMN2KMT2ATSHR | |
| SCHEMBL14469193 | 0.82 | POLB (0.43) | CYP2C19CNR1ATMLMNAPOLB | |
| SCHEMBL14469235 | 0.80 | CNR1 (0.45) | CNR1ATMPOLBHTTALDH1A1 | |
| SCHEMBL14469185 | 0.79 | CYP2C19 (0.48) | CYP2C19CNR1LMNAPOLBHTT | |
| SCHEMBL14469365 | 0.79 | KDM4E (0.48) | LMNAPOLBALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL14469298 | 0.79 | MEN1 (0.47) | ALDH1A1SMN1; SMN2KMT2ATSHR | |
| SCHEMBL14469582 | 0.79 | CNR1 (0.47) | CNR1POLBHTTSMN1; SMN2 | |
| SCHEMBL14469294 | 0.79 | ALDH1A1 (0.39) | CYP2C19CNR1LMNAPOLBALDH1A1 | |
| SCHEMBL14469366 | 0.78 | CNR1 (0.58) | CNR1LMNAPOLBALDH1A1TSHR | |
| SCHEMBL14469583 | 0.78 | POLB (0.53) | CNR1LMNAPOLBHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |