Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14469573 | 0.89 | MTNR1B (0.39) | KDM4EPOLBTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL14469563 | 0.89 | KDM4E (0.37) | KDM4EPOLBTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL14469188 | 0.86 | ALDH1A1 (0.46) | KDM4EPOLBTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL14469170 | 0.85 | KDM4E (0.48) | KDM4ETSHRSMN1; SMN2ALDH1A1ALOX15 | |
| SCHEMBL14469294 | 0.85 | ALDH1A1 (0.39) | POLBTSHRSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL14469187 | 0.84 | MEN1 (0.43) | KDM4EPOLBTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL14469186 | 0.83 | ALDH1A1 (0.47) | KDM4ETSHRSMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL14469296 | 0.82 | KMT2A (0.43) | KDM4EPOLBTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL14469298 | 0.82 | MEN1 (0.47) | KDM4ETSHRSMN1; SMN2ALDH1A1ALOX15 | |
| SCHEMBL14469299 | 0.81 | ALDH1A1 (0.36) | KDM4EPOLBTSHRSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |