Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.35 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.34 |
| ▸ | CD38 | P28907 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16184198 | 0.92 | TGFBR1 (0.38) | TGFBR1TGFBR2CD38KDM4EALDH1A1 | |
| SCHEMBL16184182 | 0.89 | CYP1A2 (0.41) | KDM4EALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL16184213 | 0.86 | KIT (0.38) | CD38KDM4EALDH1A1LMNACYP1A2 | |
| SCHEMBL16184120 | 0.86 | CYP1A2 (0.45) | KDM4EALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL14358650 | 0.86 | MAP3K11 (0.38) | TGFBR1TGFBR2KDM4EALDH1A1LMNA | |
| SCHEMBL16184191 | 0.86 | PDGFRB (0.39) | TGFBR1TGFBR2CD38KDM4EALDH1A1 | |
| SCHEMBL14474673 | 0.85 | LMNA (0.38) | KDM4EALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL14474183 | 0.84 | KIT (0.39) | CD38KDM4EALDH1A1LMNACYP1A2 | |
| SCHEMBL16184205 | 0.84 | CYP3A4 (0.41) | KDM4EALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL16184206 | 0.84 | KIT (0.40) | KDM4EALDH1A1LMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013003586-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-01-03 | — | — | WO | disclosed |