Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 10/20 | 0.57 |
| ▸ | CDK1 | P06493 | 5/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | CDK4 | P11802 | 2/20 | 0.54 |
| ▸ | CDKL1 | Q00532 | 1/20 | 0.54 |
| ▸ | SYK | P43405 | 7/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | BCR | P11274 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1448311 | 0.92 | CDK2 (0.62) | CDK2CDK1KCNH2CDK4CDKL1 | |
| SCHEMBL1448361 | 0.89 | CDK2 (0.55) | CDK2CDK1CDK4SYK | |
| SCHEMBL1447609 | 0.87 | CDK2 (0.75) | CDK2CDK1KCNH2CDK4CDKL1 | |
| SCHEMBL1447113 | 0.86 | CDK2 (0.74) | CDK2CDK1KCNH2CDK4 | |
| SCHEMBL1447633 | 0.85 | CDK2 (0.59) | CDK2CDK1KCNH2CDK4CDKL1 | |
| SCHEMBL1447917 | 0.84 | CDK2 (0.71) | CDK2CDK1KCNH2CDK4CDKL1 | |
| SCHEMBL3540056 | 0.81 | CDK2 (0.61) | CDK2CDK1KCNH2CDK4CDKL1 | |
| SCHEMBL1448282 | 0.80 | CDK2 (0.59) | CDK2CDK1KCNH2CDK4CDKL1 | |
| SCHEMBL1447533 | 0.79 | CDK2 (0.82) | CDK2CDK1KCNH2CDK4CDKL1 | |
| SCHEMBL34464867 | 0.78 | CAMK2D (0.53) | CDK2CDK1CDK4SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2301928-A1 | Imidazolyl-pyrimidine compounds for use in the treatment of proliferative disorders | AstraZeneca AB (SE) | 2011-03-30 | — | — | EP | disclosed |