Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3832287 | 0.80 | SLC6A2 (0.59) | TAAR1SLC6A2SMN1; SMN2HTR2ACYP2D6 | |
| SCHEMBL2436941 | 0.80 | DRD2 (0.45) | DRD2DRD4OPRM1DRD3TAAR1 | |
| Water SCHEMBL2959270 | 0.79 | TAAR1 (0.58) | TAAR1SLC6A2SMN1; SMN2CYP2A6HTR2A | |
| SCHEMBL1421975 | 0.78 | KDM4E (0.46) | TAAR1SLC6A2KDM4ETSHR | |
| SCHEMBL451516 | 0.77 | TAAR1 (0.60) | TAAR1SLC6A2SMN1; SMN2CYP2A6HTR2A | |
| SCHEMBL21058237 | 0.77 | TAAR1 (0.54) | TAAR1SLC6A2SMN1; SMN2CYP2A6HTR2A | |
| SCHEMBL27498335 | 0.77 | SMN1; SMN2 (0.42) | DRD2DRD4OPRM1DRD3TAAR1 | |
| SCHEMBL16079189 | 0.77 | DRD2 (0.42) | DRD2DRD4OPRM1DRD3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11164072 | 0.75 | TAAR1 (0.58) | TAAR1SLC6A2SMN1; SMN2CYP2A6HTR2A | |
| Bromide SCHEMBL11038152 | 0.75 | TAAR1 (0.58) | TAAR1SLC6A2SMN1; SMN2CYP2A6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073819-B2 | Compositions, methods of use, and methods of treatment | UNIVERSITY OF SOUTH FLORIDA (US) | 2015-07-07 | — | — | US | disclosed |
| US-9073819-B2 | Compositions, methods of use, and methods of treatment | UNIVERSITY OF SOUTH FLORIDA (US) | 2015-07-07 | — | — | US | disclosed |
| US-20140221473-A1 | Compositions, Methods of Use, and Methods of Treatment | UNIVERSITY OF SOUTH FLORIDA | 2014-08-07 | — | — | US | disclosed |
| US-20140221473-A1 | Compositions, Methods of Use, and Methods of Treatment | UNIVERSITY OF SOUTH FLORIDA | 2014-08-07 | — | — | US | disclosed |
| WO-2013003669-A2 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221473-A1 | Compositions, Methods of Use, and Methods of Treatment | KCNQ5, KCNQ3, KCNQ2 | DRD2 510/4885DRD4 815/4885OPRM1 369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.