Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1448414 | 1.00 | LMNA (0.36) | LMNAL3MBTL1KMT2AMEN1ALOX15 | |
| SCHEMBL5694243 | 0.82 | LMNA (0.37) | LMNAL3MBTL1KMT2AMEN1ALOX15 | |
| SCHEMBL5694245 | 0.82 | LMNA (0.37) | LMNAL3MBTL1KMT2AMEN1ALOX15 | |
| SCHEMBL14104713 | 0.81 | LMNA (0.36) | LMNAL3MBTL1KMT2AMEN1ALOX15 | |
| SCHEMBL27266513 | 0.69 | ALDH1A1 (0.31) | LMNAMAPTALDH1A1HTTHBB | |
| SCHEMBL12104174 | 0.69 | — | — | |
| Water SCHEMBL28300312 | 0.68 | ALDH1A1 (0.31) | LMNAMAPTALDH1A1HTTHBB | |
| Water SCHEMBL27589624 | 0.68 | ALDH1A1 (0.31) | LMNAMAPTALDH1A1HTTHBB | |
| SCHEMBL1448444 | 0.67 | MEN1 (0.35) | LMNAKMT2AMEN1ALOX15RECQL | |
| SCHEMBL1448445 | 0.67 | MEN1 (0.35) | LMNAKMT2AMEN1ALOX15RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170008855-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | ADAMA MAKHTESHIM LTD. (IL) | 2017-01-12 | — | — | US | disclosed |
| US-20150111851-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | ADAMA MAKHTESHIM LTD. (IL) | 2015-04-23 | — | — | US | disclosed |
| US-8916579-B2 | 5-fluoropyrimidinone derivatives | DOW AGROSCIENCES, LLC. (US) | 2014-12-23 | — | — | US | disclosed |
| US-20110053891-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | DOW AGROSCIENCES LLC (US) | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170008855-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | DDT, CASP5, CYP3A5 | LMNA 4528/4885L3MBTL1 1489/4885KMT2A 3314/4885 |
| US-20150111851-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | DDT, CASP5, CYP3A5 | LMNA 4528/4885L3MBTL1 1489/4885KMT2A 3314/4885 |
| US-20110053891-A1 | 5-FLUOROPYRIMIDINONE DERIVATIVES | DDT, CASP5, CYP3A5 | LMNA 4528/4885L3MBTL1 1489/4885KMT2A 3314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.