Sugi Predict

Sugi Predict / Compounds / SCHEMBL1448423

SCHEMBL1448423

SCHEMBL1448423

Cc1ccc(COc2ncc(F)c(NCc3ccccc3F)n2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.46
▸ MAPT P10636 2/20 0.46
▸ HTT P42858 1/20 0.46
▸ TDP1 Q9NUW8 1/20 0.46
▸ MAOB P27338 1/20 0.41
▸ MEN1 O00255 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ SMN1; SMN2 Q16637 2/20 0.40
▸ ALDH1A1 P00352 2/20 0.38
▸ SLC26A6 Q9BXS9 2/20 0.38
▸ USP2 O75604 1/20 0.38
▸ CYP1A2 P05177 1/20 0.38
▸ CYP3A4 P08684 1/20 0.38
▸ CYP2C9 P11712 1/20 0.38
▸ TSHR P16473 1/20 0.38
▸ KDM4E B2RXH2 2/20 0.38
▸ ABL1 P00519 1/20 0.38
▸ SRC P12931 1/20 0.38
▸ TP53 P04637 1/20 0.38
▸ POLB P06746 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3185270 0.91 MAOB (0.45) LMNAHTTMAOBMEN1KMT2A
SCHEMBL13530454 0.90 ALDH1A1 (0.46) LMNAMAPTTDP1MEN1KMT2A
SCHEMBL13529678 0.89 MEN1 (0.44) MAPTHTTTDP1MAOBMEN1
SCHEMBL13530631 0.88 MEN1 (0.49) LMNAMAPTHTTMAOBMEN1
SCHEMBL13530419 0.88 KDM4E (0.42) MAPTHTTMEN1KMT2AALDH1A1
SCHEMBL13530623 0.87 SMN1; SMN2 (0.43) LMNAHTTMEN1KMT2ASMN1; SMN2
SCHEMBL13530512 0.86 MAPT (0.45) LMNAMAPTHTTTDP1MAOB
SCHEMBL13530559 0.86 PTK2 (0.40) MAOBMEN1KMT2AALDH1A1KDM4E
SCHEMBL13530527 0.86 MAOB (0.46) LMNAMAOBMEN1KMT2ASMN1; SMN2
SCHEMBL17012512 0.85 ALDH1A1 (0.43) LMNAMAPTHTTMAOBMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170008855-A1 5-FLUOROPYRIMIDINONE DERIVATIVES ADAMA MAKHTESHIM LTD. (IL) 2017-01-12 — — US disclosed
US-20170008855-A1 5-FLUOROPYRIMIDINONE DERIVATIVES ADAMA MAKHTESHIM LTD. (IL) 2017-01-12 — — US disclosed
US-20170008855-A1 5-FLUOROPYRIMIDINONE DERIVATIVES ADAMA MAKHTESHIM LTD. (IL) 2017-01-12 — — US disclosed
US-9204653-B2 5-fluoro pyrimidine derivatives DOW AGROSCIENCES LLC (US) 2015-12-08 — — US disclosed
US-9204653-B2 5-fluoro pyrimidine derivatives DOW AGROSCIENCES LLC (US) 2015-12-08 — — US disclosed
US-9174970-B2 5-fluoro pyrimidine derivatives DOW AGROSCIENCES LLC (US) 2015-11-03 — — US disclosed
US-9174970-B2 5-fluoro pyrimidine derivatives DOW AGROSCIENCES LLC (US) 2015-11-03 — — US disclosed
EP-2252594-B1 4-AMINO-5-FLUORO-PYRIMIDINE DERIVATIVES AS FUNGICIDES DOW AGROSCIENCES LLC (US) 2015-08-19 — — EP disclosed
US-20150111851-A1 5-FLUOROPYRIMIDINONE DERIVATIVES ADAMA MAKHTESHIM LTD. (IL) 2015-04-23 — — US disclosed
US-20150111851-A1 5-FLUOROPYRIMIDINONE DERIVATIVES ADAMA MAKHTESHIM LTD. (IL) 2015-04-23 — — US disclosed
US-20140024616-A1 5-FLUORO PYRIMIDINE DERIVATIVES DOW AGROSCIENCES LLC (US) 2014-01-23 — — US disclosed
US-20110053891-A1 5-FLUOROPYRIMIDINONE DERIVATIVES DOW AGROSCIENCES LLC (US) 2011-03-03 — — US disclosed
US-20110053891-A1 5-FLUOROPYRIMIDINONE DERIVATIVES DOW AGROSCIENCES LLC (US) 2011-03-03 — — US disclosed
US-20110053891-A1 5-FLUOROPYRIMIDINONE DERIVATIVES DOW AGROSCIENCES LLC (US) 2011-03-03 — — US disclosed
WO-2011017540-A1 5-FLUOROPYRIMIDINONE DERIVATIVES DOW AGROSCIENCES LLC (US) 2011-02-10 — — WO disclosed
US-20100022538-A1 5-FLUORO PYRIMIDINE DERIVATIVES DOW AGROSCIENCES LLC (US) 2010-01-28 — — US disclosed
US-20100022538-A1 5-FLUORO PYRIMIDINE DERIVATIVES DOW AGROSCIENCES LLC (US) 2010-01-28 — — US disclosed
US-20090203647-A1 5-FLUORO PYRIMIDINE DERIVATIVES DOW AGROSCIENCES LLC (US) 2009-08-13 — — US disclosed
US-20090203647-A1 5-FLUORO PYRIMIDINE DERIVATIVES DOW AGROSCIENCES LLC (US) 2009-08-13 — — US disclosed
WO-2009094442-A2 5-FLUORO PYRIMIDINE DERIVATIVES DOW AGROSCIENCES LLC (US) 2009-07-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100022538-A1 5-FLUORO PYRIMIDINE DERIVATIVES DPYD, DPM1, DDX5 LMNA 4636/4885MAPT 3308/4885HTT 4162/4885
US-20140024616-A1 5-FLUORO PYRIMIDINE DERIVATIVES DPYD, DPM1, DDX5 LMNA 4636/4885MAPT 3308/4885HTT 4162/4885
US-20090203647-A1 5-FLUORO PYRIMIDINE DERIVATIVES DPYD, DPM1, DDX5 LMNA 4636/4885MAPT 3308/4885HTT 4162/4885
US-20170008855-A1 5-FLUOROPYRIMIDINONE DERIVATIVES DDT, CASP5, CYP3A5 LMNA 4528/4885MAPT 3328/4885HTT 3995/4885
US-20150111851-A1 5-FLUOROPYRIMIDINONE DERIVATIVES DDT, CASP5, CYP3A5 LMNA 4528/4885MAPT 3328/4885HTT 3995/4885
US-20110053891-A1 5-FLUOROPYRIMIDINONE DERIVATIVES DDT, CASP5, CYP3A5 LMNA 4528/4885MAPT 3328/4885HTT 3995/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.