Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14592486 | 0.86 | POLB (0.56) | POLBTDP1NPC1MEN1KMT2A | |
| SCHEMBL11278773 | 0.82 | POLB (0.61) | POLBTDP1NPC1MEN1KMT2A | |
| SCHEMBL14372448 | 0.77 | POLB (0.63) | POLBTDP1NPC1MEN1KMT2A | |
| SCHEMBL14524241 | 0.77 | POLB (0.67) | POLBTDP1MEN1KMT2AHRH1 | |
| SCHEMBL6036357 | 0.77 | POLB (0.55) | POLBTDP1NPC1MEN1KMT2A | |
| SCHEMBL9843189 | 0.77 | POLB (0.55) | POLBTDP1NPC1MEN1KMT2A | |
| SCHEMBL17131153 | 0.77 | POLB (0.58) | POLBTDP1NPC1MEN1KMT2A | |
| SCHEMBL1725500 | 0.77 | POLB (0.55) | POLBTDP1NPC1MEN1KMT2A | |
| SCHEMBL11362085 | 0.76 | POLB (0.51) | POLBTDP1NPC1MEN1KMT2A | |
| SCHEMBL11283425 | 0.75 | CNR1 (0.55) | POLBTDP1NPC1HRH1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235666-B2 | Sulfonation of 3-(hydroxymethyl)-5,5-diphenylimidazolidine-2,4-dione followed by phosphating in the presence of trisubstituted aliphatic amine base and a polar aprotic solvent; anticonvulsants, antiepileptic and antiarrhythmia agent | CILAG LTD. (CH) | 2007-06-26 | — | — | US | disclosed |
| US-7235666-B2 | Sulfonation of 3-(hydroxymethyl)-5,5-diphenylimidazolidine-2,4-dione followed by phosphating in the presence of trisubstituted aliphatic amine base and a polar aprotic solvent; anticonvulsants, antiepileptic and antiarrhythmia agent | CILAG LTD. (CH) | 2007-06-26 | — | — | US | disclosed |