Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11278773 | 0.81 | POLB (0.61) | POLBTDP1HRH1HRH3CNR1 | |
| SCHEMBL7854933 | 0.79 | POLB (0.62) | POLBTDP1HRH1HRH3CNR1 | |
| SCHEMBL6036357 | 0.79 | POLB (0.55) | POLBTDP1HRH1HRH3CNR1 | |
| SCHEMBL17131153 | 0.79 | POLB (0.58) | POLBTDP1HRH1HRH3CNR1 | |
| SCHEMBL1725500 | 0.79 | POLB (0.55) | POLBTDP1HRH1HRH3CNR1 | |
| SCHEMBL11283425 | 0.78 | CNR1 (0.55) | POLBTDP1HRH1HRH3CNR1 | |
| Fosphenytoin SCHEMBL119417 | 0.77 | POLB (0.52) | POLBTDP1HRH1HRH3CNR1 | |
| SCHEMBL14484233 | 0.77 | POLB (0.56) | POLBTDP1HRH1HRH3CNR1 | |
| Fosphenytoin SCHEMBL94254 | 0.77 | POLB (0.56) | POLBTDP1HRH1HRH3CNR1 | |
| Fosphenytoin SCHEMBL20769774 | 0.77 | POLB (0.56) | POLBTDP1HRH1HRH3CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4260769-A | 5,5-Diphenylhydantoins | INTERX RESEARCH CORPORATION (US) | 1981-04-07 | — | — | US | claimed |
| EP-0427925-A2 | Use of prophenytoin for preparing pharmaceutical preparations for treating stroke and cerebral ischemia | WARNER-LAMBERT COMPANY (US) | 1991-05-22 | — | — | EP | disclosed |