Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6036357 | 0.84 | POLB (0.55) | POLBNPC1TDP1MEN1KMT2A | |
| SCHEMBL11283425 | 0.83 | CNR1 (0.55) | POLBNPC1TDP1CNR1HRH1 | |
| SCHEMBL7854954 | 0.83 | POLB (0.53) | POLBNPC1TDP1MEN1KMT2A | |
| SCHEMBL14372448 | 0.82 | POLB (0.63) | POLBNPC1TDP1MEN1KMT2A | |
| SCHEMBL14484233 | 0.82 | POLB (0.56) | POLBNPC1TDP1MEN1KMT2A | |
| SCHEMBL14524241 | 0.81 | POLB (0.67) | POLBTDP1MEN1KMT2ACNR1 | |
| SCHEMBL1725500 | 0.81 | POLB (0.55) | POLBNPC1TDP1MEN1KMT2A | |
| SCHEMBL17131153 | 0.81 | POLB (0.58) | POLBNPC1TDP1MEN1KMT2A | |
| SCHEMBL10575779 | 0.81 | AKR1B1 (0.55) | POLBNPC1LMNA | |
| SCHEMBL9843189 | 0.81 | POLB (0.55) | POLBNPC1TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017133517-A1 | PHOSPHAMIDE DERIVATIVE, METHOD FOR MANUFACTURING THE SAME, AND USES THEREOF | 四川海思科制药有限公司 | 2017-08-10 | — | — | WO | disclosed |
| US-4339454-A | ANTICONVULSANTS | COLGATE-PALMOLIVE COMPANY (US) | 1982-07-13 | — | — | US | disclosed |
| US-4249005-A | NON-HYPNOTIC ANTICONVULSIVE | BRISTOL-MYERS COMPANY (US) | 1981-02-03 | — | — | US | disclosed |
| US-4046894-A | Certain barbituric acid derivatives used as anticonvulsant agents | BRISTOL-MYERS COMPANY (US) | 1977-09-06 | — | — | US | disclosed |