Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.43 |
| ▸ | CTSD | P07339 | 11/20 | 0.41 |
| ▸ | F12 | P00748 | 1/20 | 0.38 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.38 |
| ▸ | KLK1 | P06870 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14486266 | 0.86 | KLKB1 (0.49) | CPB2CTSDF12F2RL1KLKB1 | |
| SCHEMBL15901415 | 0.86 | KLKB1 (0.49) | CPB2CTSDF12F2RL1KLKB1 | |
| SCHEMBL14485435 | 0.78 | KLKB1 (0.47) | CPB2F12KLKB1KLK1 | |
| SCHEMBL14485956 | 0.78 | KLKB1 (0.61) | CPB2CTSDF2RL1KLKB1KLK1 | |
| SCHEMBL14485960 | 0.78 | KLKB1 (0.61) | CPB2CTSDF2RL1KLKB1KLK1 | |
| SCHEMBL14485893 | 0.76 | KLKB1 (0.56) | CPB2F12KLKB1KLK1REN | |
| SCHEMBL14485782 | 0.74 | KLKB1 (0.44) | CPB2CTSDF12F2RL1KLKB1 | |
| SCHEMBL1431838 | 0.72 | METAP2 (0.39) | CPB2F12KLKB1KLK1 | |
| SCHEMBL14485621 | 0.67 | KLKB1 (0.57) | CPB2KLKB1KLK1REN | |
| SCHEMBL14485317 | 0.67 | KLKB1 (0.53) | CPB2F12KLKB1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729443-A1 | BENZYLAMINE DERIVATIVES AS INHIBITORS OF PLASMA KALLIKREIN | Kalvista Pharmaceuticals Limited (GB) | 2014-05-14 | — | — | EP | disclosed |
| WO-2013005045-A1 | BENZYLAMINE DERIVATIVES AS INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2013-01-10 | — | — | WO | disclosed |