Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 4/20 | 0.49 |
| ▸ | KDM4A | O75164 | 4/20 | 0.49 |
| ▸ | KDM4D | Q6B0I6 | 4/20 | 0.49 |
| ▸ | HIF1AN | Q9NWT6 | 4/20 | 0.49 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.49 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.49 |
| ▸ | KDM3B | Q7LBC6 | 3/20 | 0.49 |
| ▸ | DAO | P14920 | 2/20 | 0.46 |
| ▸ | PLA2G7 | Q13093 | 10/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14486392 | 0.92 | DAO (0.51) | KDM6BKDM4AKDM4DHIF1ANKDM5B | |
| SCHEMBL14485919 | 0.86 | DAO (0.48) | DAO | |
| SCHEMBL14486084 | 0.83 | DAO (0.53) | KDM6BKDM4AKDM4DHIF1ANKDM5B | |
| SCHEMBL14486459 | 0.82 | PLA2G7 (0.47) | KDM6BKDM4AKDM4DHIF1ANKDM5B | |
| SCHEMBL14486064 | 0.82 | LMNA (0.42) | KDM6BKDM4AKDM4DHIF1ANKDM5B | |
| SCHEMBL14486051 | 0.82 | KDM6B (0.49) | KDM6BKDM4AKDM4DHIF1ANKDM2A | |
| SCHEMBL14486209 | 0.82 | TP53 (0.52) | KDM6BKDM4AKDM4DHIF1ANKDM5B | |
| SCHEMBL14486312 | 0.82 | DAO (0.55) | KDM6BKDM4AKDM4DHIF1ANKDM5B | |
| SCHEMBL14486303 | 0.82 | DAO (0.55) | KDM6BKDM4AKDM4DHIF1ANKDM5B | |
| SCHEMBL14486402 | 0.82 | DAO (0.55) | DAOPLA2G7LMNAUSP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729453-A1 | PYRIMIDINONE COMPOUNDS AND THEIR USE | Takeda Pharmaceutical Company Limited (JP) | 2014-05-14 | — | — | EP | disclosed |
| WO-2013004995-A1 | PYRIMIDINONE COMPOUNDS AND THEIR USE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-01-10 | — | — | WO | disclosed |