SCHEMBL144880

SCHEMBL144880

O=C(O)CCSc1nc2ccccc2s1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 1.00
ALDH1A1 P00352 3/20 1.00
POLB P06746 2/20 1.00
MAPK1 P28482 2/20 1.00
HSD17B10 Q99714 2/20 1.00
HPGD P15428 1/20 1.00
TSHR P16473 1/20 1.00
CYP1A2 P05177 4/20 0.71
CYP2D6 P10635 3/20 0.71
ALOX5 P09917 3/20 0.69
RECQL P46063 2/20 0.66
APEX1 P27695 1/20 0.66
CYP2C19 P33261 3/20 0.63
CYP3A4 P08684 2/20 0.63
CYP2C9 P11712 1/20 0.63
STAT6 P42226 1/20 0.63
MAPT P10636 3/20 0.62
L3MBTL1 Q9Y468 2/20 0.61
HIF1A Q16665 1/20 0.61
NPC1 O15118 2/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29367809 1.00 SMN1; SMN2 (1.00) SMN1; SMN2ALDH1A1POLBMAPK1HSD17B10
SCHEMBL29229036 0.98 SMN1; SMN2 (0.97) SMN1; SMN2ALDH1A1POLBMAPK1HSD17B10
SCHEMBL6274961 0.92 SMN1; SMN2 (0.85) SMN1; SMN2ALDH1A1POLBMAPK1HSD17B10
SCHEMBL3497943 0.91 SMN1; SMN2 (0.84) SMN1; SMN2ALDH1A1POLBMAPK1HSD17B10
SCHEMBL10535954 0.90 SMN1; SMN2 (0.82) SMN1; SMN2ALDH1A1POLBMAPK1HSD17B10
SCHEMBL14155879 0.89 SMN1; SMN2 (0.80) SMN1; SMN2ALDH1A1POLBMAPK1HSD17B10
SCHEMBL13164429 0.89 SMN1; SMN2 (0.80) SMN1; SMN2ALDH1A1POLBMAPK1HSD17B10
Choline SCHEMBL29148516 0.87 SMN1; SMN2 (0.75) SMN1; SMN2ALDH1A1POLBMAPK1HSD17B10
SCHEMBL8984918 0.87 POLB (0.76) SMN1; SMN2ALDH1A1POLBMAPK1HSD17B10
SCHEMBL13629729 0.87 SMN1; SMN2 (0.76) SMN1; SMN2ALDH1A1POLBMAPK1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 284 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250346794-A1 ANTIFREEZE CONCENTRATE WITH CORROSION PROTECTION AND AQUEOUS COOLANT COMPOSITION PRODUCED THEREFROM BASF SE (DE) 2025-11-13 US claimed
WO-2025202044-A1 NEW COOLANT COMPOSITIONS BASF SE (DE) 2025-10-02 WO claimed
US-12180413-B2 Solid coolant concentrates and production thereof BASF SE (DE) 2024-12-31 US claimed
CN-117487443-B Low-shrinkage heavy-duty anticorrosive paint and preparation method thereof 云南云岭涂料有限公司 2024-04-05 CN claimed
US-20240110088-A1 COOLANTS WITH IMPROVED TEMPERATURE STABILITY BASF SE (DE) 2024-04-04 US claimed
US-20240052228-A1 SOLID COOLANT CONCENTRATES AND PRODUCTION THEREOF BASE SE (DE) 2024-02-15 US claimed
EP-4314188-A1 COOLANTS WITH IMPROVED TEMPERATURE STABILITY BASF SE (DE) 2024-02-07 EP claimed
CN-117487443-A Low-shrinkage middle-corrosion-resistant coating and preparation method thereof 云南云岭涂料有限公司 2024-02-02 CN claimed
EP-4305124-A1 SOLID COOLANT CONCENTRATES AND PRODUCTION THEREOF BASF SE (DE) 2024-01-17 EP claimed
CN-117043301-A Solid coolant concentrate and preparation thereof 巴斯夫欧洲公司 2023-11-10 CN claimed
US-20150203735-A1 ANTIFREEZE CONCENTRATE WITH CORROSION PROTECTION AND AQUEOUS COOLANT COMPOSITION PRODUCED THEREFROM BASF SE (DE) 2015-07-23 US claimed
US-9080093-B2 Antifreeze concentrate with corrosion protection and aqueous coolant composition produced therefrom BASF SE (DE) 2015-07-14 US claimed
EP-2686358-B1 STABILIZED URETHANE BASED SURFACE COATING BLUM HOLGER (CH) 2014-11-19 EP claimed
US-20140296223-A1 METHOD FOR REGULATING SKIN PIGMENTATION THE GENERAL HOSPITAL CORPORATION (US) 2014-10-02 US claimed
WO-2014124826-A1 ANTI-FREEZE CONCENTRATE HAVING CORROSION PROTECTION AND AQUEOUS COOLANT COMPOSITION PRODUCED THEREFROM BASF SE (DE) 2014-08-21 WO claimed
US-20140224193-A1 ANTIFREEZE CONCENTRATE WITH CORROSION PROTECTION AND AQUEOUS COOLANT COMPOSITION PRODUCED THEREFROM BASF SE (DE) 2014-08-14 US claimed
WO-2013033520-A1 A METHOD FOR REGULATING SKIN PIGMENTATION THE GENERAL HOSPITAL CORPORATION (US) 2013-03-07 WO claimed
US-8293822-B2 Rubber-metal composite and pneumatic tire using the same THE YOKOHAMA RUBBER CO. LTD (JP) 2012-10-23 US claimed
US-20110263761-A1 RUBBER-METAL COMPOSITE AND PNEUMATIC TIRE USING THE SAME THE YOKOHAMA RUBBER CO., LTD. (JP) 2011-10-27 US claimed
US-20070145334-A1 Volatile corrosion inhibitor and molding material and molded article using the same CHUBU CHELEST CO., LTD. (JP) 2007-06-28 US claimed