Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 8/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14488136 | 0.89 | ABCC1 (0.40) | ABCC1FAAHMEN1KMT2ANPC1 | |
| SCHEMBL14488408 | 0.87 | KDM4E (0.40) | FAAHMEN1KMT2ANPC1RAB9A | |
| SCHEMBL14488441 | 0.85 | KDM4E (0.43) | FAAHMEN1KMT2ANPC1RAB9A | |
| SCHEMBL14486930 | 0.85 | KMT2A (0.50) | FAAHMEN1KMT2ANPC1RAB9A | |
| SCHEMBL14486245 | 0.85 | KMT2A (0.50) | FAAHMEN1KMT2ANPC1RAB9A | |
| SCHEMBL14486574 | 0.83 | FAAH (0.46) | FAAHDRD2 | |
| SCHEMBL14486591 | 0.83 | KCNH2 (0.51) | ABCC1FAAHNPC1RAB9AADRA1D | |
| SCHEMBL14488300 | 0.83 | FAAH (0.40) | FAAHMEN1KMT2ANPC1RAB9A | |
| SCHEMBL14486564 | 0.83 | HRH3 (0.47) | ABCC1FAAHADRA1DADRA1AADRA1B | |
| SCHEMBL14486474 | 0.79 | KMT2A (0.47) | FAAHMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726470-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | reMynd NV (BE) | 2014-05-07 | — | — | EP | claimed |
| WO-2013004642-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | REMYND NV (BE) | 2013-01-10 | — | — | WO | claimed |