Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 5/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14488136 | 0.94 | ABCC1 (0.40) | KDM4ELMNAFAAHADRA1DADRA1A | |
| SCHEMBL14486434 | 0.87 | FAAH (0.44) | FAAHADRA1DADRA1AADRA1BKCNJ1 | |
| SCHEMBL14486474 | 0.87 | KMT2A (0.47) | KDM4ELMNAFAAHRAB9AMEN1 | |
| SCHEMBL14488209 | 0.87 | ABCC1 (0.39) | FAAHADRA1DADRA1AADRA1BRAB9A | |
| SCHEMBL14486275 | 0.84 | KCNH2 (0.52) | FAAHADRA1DADRA1AADRA1BKCNJ1 | |
| SCHEMBL14486245 | 0.84 | KMT2A (0.50) | KDM4ELMNAFAAHRAB9AMEN1 | |
| SCHEMBL14486605 | 0.83 | KCNJ1 (0.45) | LMNAFAAHADRA1DADRA1AADRA1B | |
| SCHEMBL14488441 | 0.82 | KDM4E (0.43) | KDM4ELMNAFAAHADRA1DADRA1A | |
| SCHEMBL14488219 | 0.82 | ALDH1A1 (0.47) | KDM4ELMNAFAAHADRA1DADRA1A | |
| SCHEMBL14486545 | 0.81 | CYP1A2 (0.45) | LMNAFAAHRAB9ANPC1KCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726470-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | reMynd NV (BE) | 2014-05-07 | — | — | EP | disclosed |
| WO-2013004642-A1 | 1, 2, 4 -THIADIAZOL- 5 -YLPIPERAZINE DERIVATIVES USEFUL IN THE TREATMENT NEURODEGENERATIVE DISEASES | REMYND NV (BE) | 2013-01-10 | — | — | WO | disclosed |