Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.30 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16652179 | 0.80 | POLB (0.66) | POLBALDH1A1PKMCYP2A6MAPT | |
| SCHEMBL1491136 | 0.78 | POLB (0.69) | POLBKDM4EALDH1A1PKMMEN1 | |
| SCHEMBL433371 | 0.74 | POLB (1.00) | POLBKDM4EALDH1A1PKMMEN1 | |
| SCHEMBL5306978 | 0.71 | POLB (0.64) | POLBKDM4EALDH1A1PKMMEN1 | |
| SCHEMBL1491089 | 0.71 | POLB (0.64) | POLBKDM4EALDH1A1MEN1MAPT | |
| SCHEMBL4951229 | 0.71 | POLB (0.64) | POLBKDM4EALDH1A1CYP2A6MEN1 | |
| SCHEMBL1247688 | 0.71 | POLB (0.64) | POLBKDM4EALDH1A1MEN1MAPT | |
| SCHEMBL1491115 | 0.71 | POLB (0.64) | POLBKDM4EALDH1A1MEN1MAPT | |
| SCHEMBL23780337 | 0.69 | HCAR2 (0.41) | POLBKDM4EALDH1A1GRM1GAA | |
| SCHEMBL15428658 | 0.69 | POLB (0.57) | POLBKDM4EALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013004617-A1 | PYRAZOLOPYRIDINES USEFUL IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM | H. LUNDBECK A/S (DK) | 2013-01-10 | — | — | WO | disclosed |