Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | GPR142 | Q7Z601 | 9/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6125959 | 0.78 | GRIN2D (0.60) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL14480790 | 0.77 | GPR142 (0.68) | GPR142PIK3CA | |
| SCHEMBL1989631 | 0.76 | GRIN2D (0.46) | GPR142GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL21780433 | 0.75 | GPR142 (0.48) | GPR142PIK3CA | |
| SCHEMBL856861 | 0.75 | PIK3CA (0.54) | PIK3CAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL14481345 | 0.75 | GPR142 (0.71) | GPR142PIK3CA | |
| SCHEMBL4566908 | 0.75 | GPR142 (0.40) | GPR142GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL14894034 | 0.73 | BCHE (0.56) | BCHEACHEBACE1GRIN2DGRIN3B | |
| SCHEMBL4566910 | 0.71 | GRIN2D (0.39) | GPR142PIK3CAGRIN2DGRIN3BGRIN1 | |
| SCHEMBL20384834 | 0.71 | GPR142 (0.40) | GPR142PIK3CAGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726469-A1 | OXAZEPINES AS ION CHANNEL MODULATORS | Gilead Sciences, Inc. (US) | 2014-05-07 | — | — | EP | disclosed |
| WO-2013006463-A1 | OXAZEPINES AS ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. (US) | 2013-01-10 | — | — | WO | disclosed |