Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 11/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31022106 | 0.79 | HRH3 (0.46) | KIF11HRH3 | |
| SCHEMBL16209103 | 0.79 | HRH3 (0.46) | KIF11HRH3 | |
| SCHEMBL14488592 | 0.75 | BCHE (0.50) | GPR142PIK3CA | |
| SCHEMBL24258525 | 0.75 | CREBBP (0.62) | GPR142PIK3CACA12CA9 | |
| SCHEMBL14480862 | 0.72 | GPR142 (0.55) | GPR142PIK3CACYP2D6 | |
| SCHEMBL21802581 | 0.72 | PIK3CA (0.61) | GPR142PIK3CAMTOR | |
| SCHEMBL7236157 | 0.72 | ITGB2 (0.40) | — | |
| SCHEMBL14552573 | 0.72 | GPR142 (0.54) | GPR142PIK3CACYP2D6 | |
| SCHEMBL14480790 | 0.71 | GPR142 (0.68) | GPR142PIK3CAMTOR | |
| SCHEMBL21829049 | 0.71 | GPR142 (0.54) | GPR142PIK3CACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3101013-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-10-21 | — | — | EP | disclosed |
| EP-3085696-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-03-04 | — | — | EP | disclosed |