Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 13/20 | 0.51 |
| ▸ | CTSB | P07858 | 6/20 | 0.41 |
| ▸ | CTSL | P07711 | 6/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | CTSH | P09668 | 1/20 | 0.41 |
| ▸ | CTSC | P53634 | 1/20 | 0.41 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.37 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.37 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.37 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.37 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.37 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.37 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.37 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.37 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.37 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.37 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6636267 | 1.00 | CTSS (0.51) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL14427114 | 0.89 | CTSS (0.52) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL6630641 | 0.89 | CTSS (0.52) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL14427108 | 0.85 | CTSS (0.51) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL7043174 | 0.85 | CTSS (0.51) | CTSS | |
| SCHEMBL14427112 | 0.85 | CTSS (0.51) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL14427076 | 0.83 | CTSS (0.53) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL14427088 | 0.83 | CTSS (0.53) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL14562966 | 0.81 | CTSS (0.39) | CTSSCTSBCTSLCTSK | |
| SCHEMBL5424808 | 0.81 | CTSS (0.39) | CTSSCTSBCTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7226921-B2 | Compounds and compositions as cathepsin S inhibitors | AVENTIS PHARMACEUTICALS INC. (US) | 2007-06-05 | — | — | US | disclosed |
| US-7226921-B2 | Compounds and compositions as cathepsin S inhibitors | AVENTIS PHARMACEUTICALS INC. (US) | 2007-06-05 | — | — | US | disclosed |