SCHEMBL14488997

SCHEMBL14488997

Cc1cc(NC(=O)C(=O)O)c2c(c1Oc1ccc(O)c(S(=O)(=O)CC3CCCC3)c1)CCC2

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRB P10828 20/20 0.61
THRA P10827 16/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14488981 0.99 THRB (0.61) THRBTHRA
SCHEMBL14488837 0.98 THRB (0.61) THRBTHRA
SCHEMBL14488821 0.97 THRB (0.62) THRBTHRA
SCHEMBL14489103 0.90 THRB (0.70) THRBTHRA
SCHEMBL14488958 0.90 THRB (0.59) THRBTHRA
SCHEMBL14488982 0.90 THRB (0.58) THRBTHRA
SCHEMBL14489114 0.90 THRB (0.72) THRBTHRA
SCHEMBL14488974 0.89 THRB (0.61) THRBTHRA
SCHEMBL14488925 0.89 THRB (0.71) THRBTHRA
SCHEMBL14488972 0.88 THRB (0.57) THRBTHRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7230031-B2 Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof KISSEI PHARMACEUTICAL CO., LTD. (JP) 2007-06-12 US disclosed
US-7230031-B2 Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof KISSEI PHARMACEUTICAL CO., LTD. (JP) 2007-06-12 US disclosed