Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 11/20 | 0.51 |
| ▸ | THRA | P10827 | 3/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14488858 | 0.99 | THRB (0.53) | THRBTHRAHSP90AA1PARP1AURKA | |
| SCHEMBL7042657 | 0.85 | THRB (0.56) | THRBTHRAHSP90AA1PARP1ALDH1A1 | |
| SCHEMBL7040403 | 0.84 | THRB (0.57) | THRBTHRAHSP90AA1PARP1ALDH1A1 | |
| SCHEMBL14488987 | 0.82 | THRB (0.52) | THRBTHRAALDH1A1 | |
| SCHEMBL14488977 | 0.82 | THRB (0.53) | THRBTHRAAURKAAURKBALDH1A1 | |
| SCHEMBL14488988 | 0.82 | THRB (0.53) | THRBTHRAALDH1A1 | |
| SCHEMBL14488980 | 0.81 | THRB (0.54) | THRBTHRAALDH1A1 | |
| SCHEMBL14488845 | 0.79 | THRB (0.46) | THRBTHRA | |
| SCHEMBL14488851 | 0.78 | THRB (0.40) | THRBTHRAALDH1A1 | |
| SCHEMBL14489323 | 0.77 | THRB (0.39) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230031-B2 | Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2007-06-12 | — | — | US | disclosed |
| US-7230031-B2 | Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2007-06-12 | — | — | US | disclosed |