Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 16/20 | 0.52 |
| ▸ | THRA | P10827 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | COMT | P21964 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14488988 | 0.99 | THRB (0.53) | THRBTHRAALDH1A1KMT2A | |
| SCHEMBL14489017 | 0.91 | THRB (0.45) | THRBTHRA | |
| SCHEMBL14489323 | 0.86 | THRB (0.39) | THRBTHRA | |
| SCHEMBL14488826 | 0.84 | THRB (0.51) | THRBTHRAALDH1A1KMT2A | |
| SCHEMBL14489016 | 0.82 | THRB (0.51) | THRBTHRAALDH1A1 | |
| SCHEMBL14488858 | 0.82 | THRB (0.53) | THRBTHRAALDH1A1 | |
| SCHEMBL14488845 | 0.79 | THRB (0.46) | THRBTHRA | |
| SCHEMBL14488977 | 0.75 | THRB (0.53) | THRBTHRAALDH1A1 | |
| SCHEMBL14488980 | 0.75 | THRB (0.54) | THRBTHRAALDH1A1 | |
| SCHEMBL14488851 | 0.73 | THRB (0.40) | THRBTHRAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230031-B2 | Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2007-06-12 | — | — | US | disclosed |
| US-7230031-B2 | Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2007-06-12 | — | — | US | disclosed |