SCHEMBL14489161

SCHEMBL14489161

Cc1cc(NC(=O)C(=O)O)c2c(c1Oc1ccc(O)c(S(=O)(=O)NC3CCCCC3)c1)CCC2

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRB P10828 20/20 0.61
THRA P10827 15/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14488818 0.96 THRB (0.64) THRBTHRA
SCHEMBL14489089 0.87 THRB (0.66) THRBTHRA
SCHEMBL14488954 0.87 THRB (0.51) THRBTHRA
SCHEMBL7513989 0.86 THRB (0.55) THRBTHRA
SCHEMBL14489091 0.86 THRB (0.67) THRBTHRA
SCHEMBL14489137 0.85 THRB (0.71) THRBTHRA
SCHEMBL14488963 0.85 THRB (0.66) THRBTHRA
SCHEMBL14488981 0.85 THRB (0.61) THRBTHRA
SCHEMBL14488978 0.85 THRB (0.70) THRBTHRA
SCHEMBL14488997 0.84 THRB (0.61) THRBTHRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7230031-B2 Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof KISSEI PHARMACEUTICAL CO., LTD. (JP) 2007-06-12 US disclosed