SCHEMBL14489170

SCHEMBL14489170

CCOC(=O)C(=O)Nc1cc(Cl)c(Oc2ccc(O)c(CCC3CCCCC3)c2)c2c1CCC2

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRB P10828 20/20 0.66
THRA P10827 17/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14489210 0.91 THRB (0.54) THRBTHRA
SCHEMBL14489330 0.90 THRB (0.54) THRBTHRA
SCHEMBL14489281 0.89 THRB (0.69) THRBTHRA
SCHEMBL14489337 0.85 THRB (0.48) THRBTHRA
SCHEMBL14489354 0.84 THRB (0.66) THRBTHRA
SCHEMBL14489221 0.83 THRB (0.61) THRBTHRA
SCHEMBL5399563 0.83 THRB (0.63) THRBTHRA
SCHEMBL5408001 0.83 THRB (0.84) THRBTHRA
SCHEMBL5391414 0.83 THRB (0.62) THRBTHRA
SCHEMBL14489277 0.82 THRB (0.48) THRBTHRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7230031-B2 Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof KISSEI PHARMACEUTICAL CO., LTD. (JP) 2007-06-12 US disclosed
US-7230031-B2 Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof KISSEI PHARMACEUTICAL CO., LTD. (JP) 2007-06-12 US disclosed