SCHEMBL14489221

SCHEMBL14489221

CCOC(=O)C(=O)Nc1cc(Cl)c(Oc2ccc(O)c(CCc3ccc(O)c(F)c3)c2)c2c1CCC2

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRB P10828 19/20 0.61
THRA P10827 16/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14489354 0.93 THRB (0.66) THRBTHRA
SCHEMBL14489311 0.89 THRB (0.63) THRBTHRA
SCHEMBL5413308 0.85 THRB (0.77) THRBTHRA
SCHEMBL5402688 0.83 THRB (0.77) THRBTHRA
SCHEMBL14489170 0.83 THRB (0.66) THRBTHRA
SCHEMBL14489338 0.82 THRB (0.83) THRBTHRA
SCHEMBL14489329 0.82 THRB (0.69) THRBTHRA
SCHEMBL5407914 0.82 THRB (0.77) THRBTHRA
SCHEMBL14489277 0.81 THRB (0.48) THRBTHRA
SCHEMBL14489481 0.81 THRB (0.47) THRBTHRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7230031-B2 Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof KISSEI PHARMACEUTICAL CO., LTD. (JP) 2007-06-12 US disclosed
US-7230031-B2 Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof KISSEI PHARMACEUTICAL CO., LTD. (JP) 2007-06-12 US disclosed